Why is the ERN TRANSPLANTCHILD focused on this cross-cutting approach based on highly specialized procedures:

There is evidence that paediatric transplantation is the only curative therapeutic procedure targeted to the children population that has the highest mortality rates in their age group. The current approach is performed focused on a specific disease or organ.

However, there are many common complications due to the need to suppress the immunological incompatibility between individuals regardless the transplanted organ.

And this is the point where ERN is focusing on: A cross-cutting transplantation ERN is needed to share the knowledge of every type of transplantations in order to enhance the outcome.

There are challenges associated with common complications and optimising the effects of these interventions, such as those associated to:

• Mechanisms of graft rejection and the occurrence of complications.

• Innovations in surgical procedures applied to these transplantations.

• The approach to chronicity and the treatment of secondary to diseases paediatric transplantation.

• Socio-economic impact of these interventions in patients, families and health systems.

A cross-cutting approach allows:

• The collection of sound findings due to the higher amount of transplantation cases. This view is specially needed in paediatric transplantation as compared to adult transplantation in which the number of patients is higher.

• The establishment of synergies from the knowledge and results from different types of transplants (e.g. knowledge in HSCT is being applied in SOT).

• The improvement of the transplant patient handling and outcomes achieved.

• The identification of common topics to all types of transplants such as clinical, personal and socio-economic issues.

• The integration and share of knowledge and clinical expertise among all clinical teams and support departments.

• The increase of opportunities for clinical innovation towards the improvement of life expectancy and long-term quality of life of children and their families.

• The decrease of personal burden of transplantation as a chronic long-life condition.

• The provision of psycho-social support in different phases of patients’ lifes.

• The provision of grounds for patients’ empowerment.

Innovative efforts in transplantation can impact on all transplanted children, regardless the transplanted organ, in clinical areas such a surgical procedures, pharmacological toxicity, immunosuppression and its long-term consequences, tolerance and rejection, GVHD, infections, innovative biological and cellular therapies, monitoring for personalised-precision medicine, etc .

CCentral coordination
Tel.: +34 917 277 576
coordination@transchild.com www.transplantchild.com